You are not required to resolve dice results you roll unless an icon’s ability states otherwise. For example, if you roll a Wrecking Blow skill die (Two Handed level 1) and the result is 2 damage, but then realize your target enemy has Riposte and you don’t want to deal it damage, you do not need to resolve that result. Or, if you roll a Breath of Life die (Restoring Light level 2) and the result is a 2 die heal instead of a 4 die heal, you can choose not to heal.
If you decide not to use a skill die in this way, it is still exhausted, even if its use would normally cause it to be drained or placed elsewhere.