Pathfinder Adventure Card Game

Can I exchange character roles between sets?

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No
When the same characters or cohorts appear in different sets, they are represented with different cards having different abilities and powers. To distinguish between them, we add the name of the set the card came from to the card name. For example, "Core Set Ezren" is a different card than "Rise of the Runelords Ezren," so you may not exchange roles between them.