Sentinels of the Multiverse is a cooperative game in which each player controls a Hero, using their powers, abilities, and wits to work together with their fellow Heroes and save the world! Each game involves 3 to 5 Heroes fighting against 1 Villain in a perilous Environment. It can be played with 1-5 players.

The game is fully cooperative, so the Villain and Environment aren’t run by a dedicated player, but rather are controlled by turning over cards from their decks and following the instructions on those cards.

Each Hero, Villain, and Environment are represented by a deck of cards. Heroes and Villains also have character cards, which provide their Hit Points (usually abbreviated HP) and other information specific to that character.