To win Nemesis, you must earn objective points equal to or greater than what is required by the difficulty rank. You can win even if your Health is reduced below 1. If multiple heroes earn the required number of objective points, all of those heroes share in the victory.

If you do not earn enough objective points, you lose.

There is no endgame in Nemesis. Instead, the game ends when the dial reaches 0 or when all heroes have either escaped or been defeated.