Munchkin

Can I switch Items during combat?

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No
You can't switch Items during combat. In other words, you can't choose to equip a different Headgear or different Armor once combat has started. You also can't unequip one Item that uses Hands and equip another in its stead. Basically, all your Items must remain in their current states . . . even if some of them become unusable.
Related Rule(s)