Choose a player to go first. You can select a random player by using the Guardian Cards. Give the Talisman and all Guardian Cards to the chosen player. The player who has the Talisman will be the first to choose one of the Guardian Cards on any given round. Note that the Talisman can change owners during the game; it is possible for the turn order to change each round.
In a 2 player game only Guardian Cards numbered 2, 3, and 4 are used. The Talisman is always given to the other player at the end of each round.