You may choose to play the game with zero players and the game can play itself. If you do this, set up a two player game and use two Assistants. Each Assistant would have their own turn and resolve that turn as in Solo Mode. In this variant Assistants cannot share resources with each other and cannot spend Choas Tentacles to perform additional actions.
Take an extra Brain Token and place that above an Assistant card. Move it back and forth between the Assistants to keep track of which Assitant is the active player.
Each Assistant will Spin the Wheel of Madness, resolve the Wheel, then take their actions.
When an Assistant spins () to bring a Tentacle down from the Shambler Mat to the Discard Mat , they will always choose the Tentacle that has the most on the Shambler Mat. If there is a tie for the most Tentacles, then choose the left most Tentacle of the tied Tentacles.
When drawing Tentacles from the bag after moving, Chaos Tentacles will remain with the Assistant that drew them.