When both locations of a single color have been sealed, that portal color is now closed. When a portal color is sealed the Great Old One will be weakened further and two things occur.
1. That color power will be turned off and will no longer trigger on the Wheel of Madness or by Accurssing the matching color Madness Track on a Town Card.
2. Move all the matching color Tentacles from the Shambler Mat down to the Discard Mat.